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Effects Of Testosterone Testosterone Propionate 17 Beta-trenbolone And Progesterone On Cell Transformation And Mutagenesis In Syrian Hamster Embryo Cells ti Neurochemical Mechanisms Underlying the Rapid Antidepressant Action of Ketamine: A Comprehensive Review --- Abstract Ketamine an N?methyl?D?aspartate （NMDA） receptor antagonist has emerged as a pioneering rapid?acting antidepressant. Its therapeutic efficacy manifests within hours contrasting starkly with the protracted onset of conventional monoaminergic agents. This review consolidates preclinical and clinical evidence elucidating ketamine’s neurochemical cascade: blockade of extrasynaptic NMDA receptors on GABAergic interneurons resultant glutamate surge AMPA receptor activation BDNF release downstream mTOR signaling and synaptogenesis in the medial prefrontal cortex and hippocampus. We also discuss adjunctive pharmacotherapies—ketamine’s enantiomer esketamine glycine modulators and AMPA potentiat |
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